Graviola cancer treatment dosage, benefits, side effects, toxicity, safety and supplement dosage, studies and research, review, how effective are these pills for cancer prevention or treatment?
Can you trust testimonials regarding cures and as a powerful cancer fighter? What is the right dose for therapy for this product and the pills? Is it a hoax or scam?

February 1 2017

Graviola has been found in in vitro studies to have anti cancer potential. This has prompted many websites to advertise graviola herbal supplements as a treatment or cure for many types of cancer. Is the claim that graviola cures cancer a hoax or scam? It is difficult to say. Laboratory studies have been quite positive, but, on the other hand human research is lacking.

Human studies
As of 2017 we are not aware of human studies with graviola supplement as a treatment, cure or remedy for cancer. Despite the lack of human studies in terms of cancer prevention or treatment, many websites promote graviola supplements to cancer patients based on traditional use and promising results of in vitro studies. There are those who claim it is helpful as a therapy or prevention for cancer of the blood, breast, cervix, esophagus, liver, lymph node involvement, lung tumors, lymphoma, mouth, pancreas, prostate, spine, tongue, uterus, and others. But such claims, at this time, are myths or speculations. There is, as of now, no established protocol in using this medicinal plant.

Graviola supplements are sold over the counter in health food stores, online, and in some pharmacies. Graviola supplements are not expensive. A typical capsule has between 400 to 600 mg of the powder. Some products are extracts.

Here is a product that you can purchase online at a very reliable online store:

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Purchase Graviola supplement pills of high quality at a reliable online store

When to take: Since it has some sedating or relaxing effects, it is best taken in the evening before, with, or after dinner.

Benefits of Graviola plant

Extracts of graviola possess potent in vitro antioxidant activity.

Blood sugar, diabetes
Antidiabetic and antioxidant effects of Annona muricata aqueous extract on streptozotocin-induced diabetic rats. J Ethnopharmacol. 2014 Feb 3.

Breast cancer
Selective growth inhibition of human breast cancer cells by graviola fruit extract in vitro and in vivo involving downregulation of EGFR expression. Nutr Cancer. 2011

Colon cancer
I was operated on for colon cancer. I now have a colostomy bag and started chemotherapy drugs 2 weeks ago. I have had very few if any side effects from the chemo thank goodness. I have been studying the effects of graviola on colon cancer and like what I read. I would appreciate your thoughts and can it be taken in conjunction with chemo.
Since human research is not available regarding the role of this plant and its extract on various human cancers, it is not possible at this time to say whether this supplement is useful as an anti-tumor agent and whether it works well with chemotherapy.

Liver cancer
J Nat Prod. 2001. Novel cytotoxic annonaceous acetogenins from Annona muricata. Seven new annonaceous acetogenins, muricins, as well as five known compounds, a mixture of muricatetrocin A and muricatetrocin B, longifolicin, corossolin, and corossolone, were isolated from the seeds of Annona muricata. These acetogenins showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines Hep G(2) and 2,2,15.

My Aunt has stage 4 Liver cancer. Do you think that graviola supplement pills can help her?
It is not possible for us to predict since we have not seen human studies regarding the benefit of this herb for hepatic cancers.

Cancer Lett. 2012. Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Our experiments revealed that Graviola induced necrosis of pancreatic cancer cells by inhibiting cellular metabolism.

Graviola Cancer treatment in combination with other nutraceuticals, vitamins, herbs
Can Sulforaphane from broccoli extract be used together with graviola herbal extract for cancer therapy?
We have not seen such studies with this combination, but it is intriguing.

Molluscicidal activity
An ethanolic extract of the leaves of graviola is toxic to adult forms of the snail Biomphalaria glabrata and to larvae of the brine shrimp Artemia salina.

Graviola side effects, caution, safety and toxicity, is there a danger to using it daily for months or years?
The benefits and side effects of graviola herbal supplements are not fully understood. Graviola may sometimes cause sleepiness, sedation or relaxation. Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves which contain annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. In Guadeloupe the fruit is eaten regularly and there is concern that consumption of this fruit on a regular basis for years and decades can lead to a Parkinsonian-like syndrome. We do not know how graviola interacts with drugs used for chemotherapy. A rodent study in 2013 showed it to be non toxic and safe after high dose daily consumption for 60 days.

Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes?
Brain. 2007. Department of Neurology, Hospital of Pointe-à-Pitre, Guadeloupe island.
In Guadeloupe, there is an abnormally high frequency of atypical parkinsonism. Only one-third of the patients that develop parkinsonian symptoms were reported to present the classical features of idiopathic Parkinson disease and one-third a syndrome resembling progressive supranuclear palsy. We carried out a cross-sectional study of 160 parkinsonian patients to define more precisely the clinical phenotypes of the PSP-like syndrome and the parkinsonism that was considered unclassifiable in comparison with previously known disorders; and evaluate to what extent a candidate etiological factor, the mitochondrial complex I inhibitor annonacin contained in the fruit and leaves of the tropical plant Annona muricata (soursop) plays a role in the neurological syndrome.  In conclusion, atypical Guadeloupean parkinsonism comprises two forms of parkinsonism and dementia that differ clinically by the presence of oculomotor signs, but have similar cognitive profiles and neuroimaging features, suggesting that they may constitute a single disease entity, and both were similarly exposed to annonaceous neurotoxins, notably annonacin.

J Basic Clin Physiol Pharmacol. 2013 December. Toxicological evaluation of the lyophilized fruit juice extract of Annona muricata in rodents. Graviola fruit juice is widely consumed either raw or after processing in tropical countries because of its very juicy, creamy and sweet character including its medicinal importance. The safety was investigated in Sprague-Dawley rats for acute and 60-day subchronic toxicity effects. There was no mortality recorded up to 2000 mg/kg following acute administration. There were no significant changes in vital organ weights and hematological and biochemical parameters. However, significant reduction in platelet count and packed cell volume was observed at 2000 and 400 mg/kg, respectively, which was reversed after cessation of treatment. Interestingly, subchronic oral administration (80, 400 or 2000 mg/kg) significantly increased sperm count and motility in comparison to vehicle-treated control. Long-term treatment induced significant increases in the levels of glutathione, superoxide dismutase (SOD) and catalase, respectively, in the liver and kidney. Conversely, A2000 mg/kg produced significant increase in malondialdehyde level with decreased SOD activity in the brain. The study established that graviola did not induce any significant toxic effect, indicating that it is safe in rats following oral administration for 60 consecutive days.

Side effect stories and testimonials
I bought Graviola 6 bottles in 2010 and I’m taking it everyday 1 capsule for 5 days a week for 3 weeks. Recently I’m experiencing some side effects like heartburn even though I take it with food and supplementing myself with Probiotics everyday and taking Zantac or Nexium. Also my blood pressure is always high since I have taken Graviola. My blood pressure is 159/80. I’m a hypertensive patient and taking Atenolol 100mg, HCTZ 25mg, Cozaar (losartan) 25mg everyday. The reason why I started taking it is because I was diagnosed with breast cancer 2 years ago, had double mastectomy, chemo, radiation. Currently taking Arimidex daily also. Do you think there is a drug interaction with it and my BP meds?
it is so difficult to make a diagnosis in this case since there are many medications that can cause similar symptoms and no research has been done with such combinations.

Composition of graviola
Acetogenins, annonacin (90%), isoannonacin (6%) and goniothalamicin (4%). We are currently do not know what vitamins are in the fruit. Acetogenins, such as annonacin, might be implicated in the etiology of Guadeloupean parkinsonism when the fruit is consumed for several decades. On a positive note, acetogenins are potent inhibitors of NADH oxidase of the plasma membranes of cancer cells.

MALDI-TOF MS profiling of annonaceous acetogenins in Annona muricata products for human consumption.
Molecules. 2009.
Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented.

Combination with other dietary supplements
I recently bought a graviola supplement after hearing about it on Dr. Valerie Saxion’s program. But I read on another site a caution  when taken for cancer fighting purposes it ought not be taken concurrently with COQ10. If I recall correctly COQ10 increases ATP and thwarts the herb’s cancer fighting ability. Is this true? I have taken CoQ10 for years and now take ubiquinol. I also do yoga.
A Medline search in 2014 did not reveal any studies that have combined these two nutraceuticals.

Can graviola be used by pets, dogs or cats?
We have not seen studies using it as a cancer treatment for dogs or cats or other pets. If a person plans to give it to their dog or cat, the dose would likely be a third or quarter the amount given to an adult male or female.

Other claims besides being a cancer killer, stories, testimonials
Some websites claim it can be used for depression, but we doubt it is effective for this purpose.

Botanical name
Annona muricata is the botanical name. It is also known as soursoup.

The fruit
Soursop (Annona muricata) is a highly aromatic fruit with white juicy flesh and native to tropical North and South America. The ripe fruits are highly perishable, as they become soft and easily bruised.

Other products online or in health food stores
Graviola leaf powder 375 mg
Soursop Annona muricata Leaf 500 mg
Graviola leaf 500 mg capsules by Physician Formulas, this is a reliable brand and is available on their website.
Annona muricata in a vegetable capsule (500 mg)
Graviola extract 300 mg

Q. I have purchased 500 grams of graviola powder from Raintree Nutrition, Carson City, NV. I was curious if there was a way to determine that the product that I received is in fact derived from the graviola tree? Worked in clinical research most of my adult career in Los Angeles, My partner has developed an aggressive from of prostrate cancer. Would like to administer this as a prophylaxis against metastasis.
A. The only way to know whether a particular product, powder or pill, is true to its label is to send a sample to a lab that does HPLC testing. For most people this is not a practical step to take.